Buxtorf J C, Martin O
Pathol Biol (Paris). 1977 Feb;25(2):109-12.
Twenty-two hyperlipidemic and long-term alcoholic patients were chosen as subjects with a chronic alcohol-dependent hyperlipoproteinemia, since their lipidemia was getting normal after they stopped alochol ingestion. After ethanol-weaning of these subjects, we found quantitative abnormalities of lipidemia (hypocholesterolemia in 5 cases among 22) and qualitative abnormal electrophoretic patterns in all cases: There is always a VLDL stain, a reduction of the LDL and VLDL migration. These facts suggest that exists in these patients a constant abnormality either in the enzymatic, or in the lipoprotein structures, which is induced or revealed by alcohol ingestion.20
22名高脂血症和长期酗酒患者被选为慢性酒精依赖型高脂蛋白血症的研究对象,因为他们在停止饮酒后血脂恢复正常。在这些研究对象戒酒之后,我们发现了血脂的定量异常(22例中有5例出现低胆固醇血症)以及所有病例中电泳图谱的定性异常:始终存在极低密度脂蛋白染色,低密度脂蛋白和极低密度脂蛋白迁移率降低。这些事实表明,这些患者在酶或脂蛋白结构方面存在持续异常,这种异常是由饮酒诱发或暴露出来的。