Vangelooven Joris, De Malsche Wim, Detobel Frederik, Gardeniers Han, Desmet Gert
Department of Chemical Engineering, Vrije Universiteit Brussel, B-1050 Brussels, Belgium.
Anal Chem. 2009 Feb 1;81(3):943-52. doi: 10.1021/ac801691e.
A new flow type for the conduction of rapid chromatographic and macro-molecular separations in 1D nanochannels is reported. It combines the pressure-drop-less operation of shear-driven flows with the meandering flow paths that are present in ordered arrays of micro- and nanopillars. Similar to shear-driven flows in open channels, the achievable fluid velocity is quasi unlimited and is not affected by a pressure- or voltage-drop, while the axial dispersion in the microstructured pillar arrays remains surprisingly low. In the present paper, we report on a series of flow resistance and band broadening experiments that have been conducted to characterize the hydrodynamical properties of this new flow type. In addition, theoretical computational fluid dynamics (CFD) simulations have been performed to explain the observations. Good agreement between theory and experiment was obtained.
报道了一种用于在一维纳米通道中进行快速色谱和大分子分离的新型流动类型。它将剪切驱动流的无压降操作与微柱和纳米柱有序阵列中存在的蜿蜒流动路径相结合。与明渠中的剪切驱动流类似，可实现的流体速度几乎不受限制，且不受压降或电压降的影响，而微结构柱阵列中的轴向扩散仍然出奇地低。在本文中，我们报告了一系列为表征这种新型流动类型的流体动力学特性而进行的流动阻力和谱带展宽实验。此外，还进行了理论计算流体动力学（CFD）模拟以解释这些观察结果。理论与实验之间取得了良好的一致性。
