Fulmer A K, Mauldin G E, Mauldin G N
Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA.
Vet Comp Oncol. 2008 Dec;6(4):248-56. doi: 10.1111/j.1476-5829.2008.00162.x.
Feline oral squamous cell carcinoma (SCC) is a devastating disease with an extremely poor long-term prognosis even with aggressive therapy. Folate and homocysteine derangements are identified in people diagnosed with head and neck SCC. The purpose of this study was to measure plasma folate and homocysteine concentrations in cats diagnosed with oral SCC (n = 13) and to compare these concentrations with those found in cats diagnosed with other tumour types (n = 25), cats with oral, non-neoplastic disease (n = 6) and healthy cats (n = 24). The median plasma folate concentration in cats diagnosed with oral SCC was 14.7 ng mL(-1), while the median plasma homocysteine concentration was 2.61 microg mL(-1). These concentrations did not differ significantly from those of cats in the other groups. This suggests that different factors may contribute to the pathogenesis of this tumour in cats when compared with people, although evaluation of larger numbers of cats may still identify a difference between groups.
猫口腔鳞状细胞癌（SCC）是一种毁灭性疾病，即使进行积极治疗，其长期预后也极差。在被诊断患有头颈部鳞状细胞癌的人群中，发现了叶酸和同型半胱氨酸紊乱。本研究的目的是测量被诊断患有口腔鳞状细胞癌的猫（n = 13）的血浆叶酸和同型半胱氨酸浓度，并将这些浓度与被诊断患有其他肿瘤类型的猫（n = 25）、患有口腔非肿瘤性疾病的猫（n = 6）和健康猫（n = 24）的浓度进行比较。被诊断患有口腔鳞状细胞癌的猫的血浆叶酸浓度中位数为14.7 ng mL⁻¹，而血浆同型半胱氨酸浓度中位数为2.61 μg mL⁻¹。这些浓度与其他组猫的浓度没有显著差异。这表明，与人类相比，可能有不同的因素导致猫的这种肿瘤发病机制，尽管对更多数量的猫进行评估可能仍会发现组间差异。
