Contador-Castillo Israel, Fernández-Calvo Bernardino, Ramos Campos Francisco, Cacho Gutiérrez Laureano J, Rodríguez Pérez Roberto
Universidad de Salamanca, Spain.
Psicothema. 2009 Feb;21(1):15-20.
Non-verbal memory impairment in Alzheimer-type dementia: Forgetting or acquisition?. The research aims to compare patients diagnosed with early Alzheimer's disease (AD) and unipolar major depression (D) with a healthy control group (HS) on diverse nonverbal memory tasks (NVM), recall of position, and recognition of abstracts designs. All participants completed a global protocol for diagnosis of dementia. The patients with early AD (n= 27) and D (n= 19) were compared with the healthy subject group (n= 30) on a standardised visuospatial learning test. The AD patients scored significantly lower than HS and D on NVM tasks, but there were no significant differences between AD and D on position recall. Furthermore, the AD group did not show faster forgetting rates on position recall or design recognition in comparison to HS and D groups. These results are interpreted in terms of neurocognitive processes that explain NVM impairment in AD and depression.
遗忘还是获取?本研究旨在将被诊断为早期阿尔茨海默病(AD)和单相重度抑郁症(D)的患者与健康对照组(HS)在各种非言语记忆任务(NVM)、位置回忆和抽象图案识别方面进行比较。所有参与者都完成了痴呆诊断的综合方案。在标准化视觉空间学习测试中,将早期AD患者(n = 27)和D患者(n = 19)与健康受试者组(n = 30)进行比较。AD患者在NVM任务上的得分显著低于HS组和D组,但在位置回忆方面,AD组和D组之间没有显著差异。此外,与HS组和D组相比,AD组在位置回忆或图案识别方面没有表现出更快的遗忘率。这些结果是根据解释AD和抑郁症中NVM损伤的神经认知过程来解释的。