Chalabianloo Fatemeh, Schjøtt Jan
Seksjon for klinisk farmakologi Laboratorium for klinisk biokjemi Haukeland universitetssykehus 5021 Bergen.
Tidsskr Nor Laegeforen. 2009 Jan 29;129(3):186-7. doi: 10.4045/tidsskr.08.0047.
The aim of this paper is to assess the substance pregabaline's potential for abuse. Little information is available on the subject and that retrieved is in part conflicting. Pregabaline is likely to be abused for its positive psychological effects, e.g. euphoria. However, these effects are weak and not sustained during long-term use. Pregabaline is therefore likely to have a lower potential for abuse than benzodiazepines. In clinical studies, symptoms suggestive of physical dependence (e.g. insomnia, nausea, headache, diarrhoea) have been observed in some patients after abrupt discontinuation of pregabaline. However, available documentation indicates that pregabaline is associated with less physical and psychological dependence than benzodiazepines.
本文旨在评估普瑞巴林这种药物的滥用可能性。关于该主题的信息很少，且所检索到的部分信息相互矛盾。普瑞巴林因其积极的心理效应（如欣快感）而可能被滥用。然而，这些效应较弱，且在长期使用过程中无法持续。因此，普瑞巴林的滥用可能性可能低于苯二氮䓬类药物。在临床研究中，一些患者在突然停用普瑞巴林后出现了提示身体依赖的症状（如失眠、恶心、头痛、腹泻）。然而，现有文献表明，与苯二氮䓬类药物相比，普瑞巴林导致的身体和心理依赖较少。
