Svoboda R Paul, Patel Dhaval H, Olden Kevin W
Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Drugs Today (Barc). 2008 Nov;44(11):857-63. doi: 10.1358/dot.2008.44.11.1297916.
Budesonide is a promising drug for a variety of documented applications and has potential in gastroenterology. Its unique local mechanism of delivery and efficient first-pass metabolism, resulting in fewer systemic adverse effects than with conventional glucocorticoids, makes this a desirable drug for clinical practice. This drug has shown promise in treating a wide spectrum of inflammatory diseases from inflammatory bowel disease and other colitides to autoimmune liver diseases. Future research should focus on ways to increase delivery methods to promote long-term usage for maintenance therapy for the disease entities listed above, as well as for other potential nongastrointestinal conditions.
布地奈德是一种在多种已记录应用中颇具前景的药物，在胃肠病学领域具有潜力。其独特的局部给药机制和高效的首过代谢，与传统糖皮质激素相比，全身不良反应更少，这使其成为临床实践中理想的药物。该药物在治疗从炎症性肠病和其他结肠炎到自身免疫性肝病等广泛的炎症性疾病方面已显示出前景。未来的研究应侧重于增加给药方法，以促进对上述疾病实体以及其他潜在非胃肠道疾病进行长期维持治疗的使用。
