人体氧感知中立体电子效应的证据。
Evidence for a stereoelectronic effect in human oxygen sensing.
作者信息
Loenarz Christoph, Mecinović Jasmin, Chowdhury Rasheduzzaman, McNeill Luke A, Flashman Emily, Schofield Christopher J
机构信息
Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, Department of Chemistry, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
出版信息
Angew Chem Int Ed Engl. 2009;48(10):1784-7. doi: 10.1002/anie.200805427.
How PHDs achieve specificity: trans-4-prolyl hydroxylation of the transcription factor HIF occurs with stereochemical retention. Substrate-analogue studies show how the von Hippel Lindau tumor suppressor protein (pVHL) and the oxygen-sensing hydroxylases (PHDs) achieve specificity for hydroxyprolyl/prolyl residues for the C(4)-exo/endo prolyl conformations, respectively.
博士学位蛋白如何实现特异性
转录因子缺氧诱导因子（HIF）的反式-4-脯氨酰羟化反应具有立体化学保留。底物类似物研究表明，冯·希佩尔·林道肿瘤抑制蛋白（pVHL）和氧感应羟化酶（博士学位蛋白）分别如何针对C(4)-外/内脯氨酰构象的羟脯氨酰/脯氨酰残基实现特异性。
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