白藜芦醇抗几种呼吸道病毒作用的体外实验研究
[In vitro experimental study on the effect of resveratrol against several kinds of respiroviruses].
作者信息
Guan Wen-Da, Yang Zi-Feng, Liu Ni, Qin Sheng, Zhang Feng-Xue, Zhu Yu-Tong
机构信息
Molecular Immunology and Antibody Engineering Center, Jinan University, Guangzhou 510632, China.
出版信息
Zhong Yao Cai. 2008 Sep;31(9):1388-90.
OBJECTIVE
To observe the cytopathogenic inhibitory effect of resveratrol on vary respiroviruses and explore the mechanism of resveratrol against viruses.
METHODS
MDCK, A549, HEp-2 cell and MRC-5 were infected with Influenza virus type A FM1 strain, rhinovirus type R14, RS virus, AD virus type 7 separately, and the antiviral activity of resveratrol were observed.
RESULTS
Resveratrol significantly inhibited cytopathogenic effect of AD virus type 7 at the concentration 120 microg/ml. No significant cytopathogenic effect of Resveratrol inhibiting Influenza virus type A FM1 strain, Rhinovirus type R14, RS virus on separate cells was observed.
CONCLUSION
It is concluded that resveratrol is effective on inhibiting AD virus type 7 in vitro, however, its mechanism is needed for further study.
目的
观察白藜芦醇对多种呼吸道病毒的细胞病变抑制作用，并探讨其抗病毒机制。
方法
分别用甲型流感病毒FM1株、鼻病毒R14型、呼吸道合胞病毒、腺病毒7型感染MDCK、A549、HEp-2细胞和MRC-5细胞，观察白藜芦醇的抗病毒活性。
结果
白藜芦醇在浓度为120μg/ml时能显著抑制腺病毒7型的细胞病变效应。未观察到白藜芦醇对甲型流感病毒FM1株、鼻病毒R14型、呼吸道合胞病毒在各细胞上有明显的细胞病变抑制作用。
结论
得出白藜芦醇在体外对腺病毒7型有抑制作用，但仍需进一步研究其作用机制。
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