[热毒清口服液对呼吸道合胞病毒体外抑制作用的研究]
[Study on the inhibitory effect of Reduqing Oral Liquid on respiratory syncytial virus in vitro].
作者信息
Huang Sheng-Hai, Feng Xiao-Liang, Liu Wei
机构信息
Department of Microbiology, Anhui Medical University, Hefei 230032, China.
出版信息
Zhong Yao Cai. 2009 Apr;32(4):579-81.
OBJECTIVE
To explore the antiviral effect of Reduqing Oral Liquid on respiratory syncytial virus (RSV).
METHODS
The anti-RSV effect of Reduqing Oral Liquid in Hep-2 cell culture was investigated by the cytopathic effect (CPE) inhibition assay and MTT assay, with ribavirin as the positive control drug.
RESULTS
Reduqing Oral Liquid was effectively antiviral agent for RSV in a concentration-dependent manner in vitro. The median toxic concentration (TC50) was 9182.4 mg/L, the median effective concentration (EC50) was 559.8 mg/L and the treatment index (TI) was 16.4.
CONCLUSION
Reduqing Oral Liquid has obvious inhibitory effect on RSV in vitro.
目的
探讨热毒清口服液对呼吸道合胞病毒（RSV）的抗病毒作用。
方法
采用细胞病变效应（CPE）抑制试验和MTT试验，以利巴韦林为阳性对照药，研究热毒清口服液在Hep-2细胞培养中对RSV的抗病毒作用。
结果
热毒清口服液在体外对RSV有明显的抗病毒作用，呈浓度依赖性。半数中毒浓度（TC50）为9182.4mg/L，半数有效浓度（EC50）为559.8mg/L，治疗指数（TI）为16.4。
结论
热毒清口服液在体外对RSV有明显抑制作用。
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