Wei Lian-Bo, Deng Cong, Chen Jie-Bin, Li Yu-Ming, Huang Li-Wen, Gong Chun-Shui
Department of Nephoropathy of Western and Chinese Medicine, Zhujiang Hospital, Southern Medical University/Emphasis subject of Nephropathy of State Administration of Traditional Chinese Medicine, Guangzhou 510282, China.
Zhong Yao Cai. 2008 Sep;31(9):1391-5.
To investigate the effects of capsule of Shenshuai Yangzhen, a preparation of traditional Chinese medicine, on malnutrition rats with chronic renal failure (CRF).
SD rats received 5/6 nephrectomy for preparation of CRF models, and fed 4% casein at the same time. Observed when malnutrition began. Those consistents with malnutrition of CRF condition were randomized into model control group, Ketosteril group, Shenshuai Yangzhen group, and normal control group. After 4-weeks treatment as indicated, The blood parameters, like blood serum albumin (ALB), type-1 insulin like growth factor (IGF-1), total cholesterol (TC), triglyeride (TG), urea nitrogen (BUN), serum creatinine (Scr), haemoglobin (Hb), 24 hour urineprotein (24hUpr) and weight were determined. Nephrotic tissue was observed by microscope (included HE and PAS).
Malnutrition situation in CRF rats began at the end of 10-weeks. After 4-weeks treatment, weight in Shenshuai Yangzhen group were higher significantly (P < 0.05). Compared with model control group, blood serum BUN (P < 0.05), SCr (P < 0. 05) and 24h Upr (P < 0.001) in Shenshuai Yangzhen group were significantly lower with substantially elevated blood serum ALB, Hb, IGF-1 (P < 0.01; P < 0.001; P < 0.001, respectively). Pathology of Shenshuai Yangzhen group was a meliorated significantly after treated.
Capsule of Shenshuai Yangzhen has a possible therapic effect on improving malnutrition in rats with renal insufficiency.
探讨中药制剂肾衰养真胶囊对慢性肾衰竭（CRF）营养不良大鼠的影响。
采用5/6肾切除法制备SD大鼠CRF模型，同时喂饲4%酪蛋白，观察营养不良出现的时间。将符合CRF合并营养不良条件的大鼠随机分为模型对照组、开同组、肾衰养真组和正常对照组。按所示进行4周治疗后，测定血清白蛋白（ALB）、Ⅰ型胰岛素样生长因子（IGF-1）、总胆固醇（TC）、甘油三酯（TG）、尿素氮（BUN）、血清肌酐（Scr）、血红蛋白（Hb）、24小时尿蛋白（24hUpr）及体重等血液参数。用显微镜观察肾组织（包括HE和PAS染色）。
CRF大鼠在10周龄末出现营养不良状况。治疗4周后，肾衰养真组大鼠体重显著增加（P<0.05）。与模型对照组相比，肾衰养真组血清BUN（P<0.05）、SCr（P<0.05）及24hUpr（P<0.001）显著降低，血清ALB、Hb、IGF-1显著升高（分别为P<0.01；P<0.001；P<0.001）。肾衰养真组治疗后病理改变明显改善。
肾衰养真胶囊对改善肾功能不全大鼠的营养不良可能具有治疗作用。
