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Beta-lactam-based approach for the chemical programming of aldolase antibody 38C2.
Bioorg Med Chem Lett. 2009 Mar 1;19(5):1421-4. doi: 10.1016/j.bmcl.2009.01.028. Epub 2009 Jan 15.
2
Multiple catalytic aldolase antibodies suitable for chemical programming.
Bioorg Med Chem Lett. 2009 Jul 15;19(14):3821-4. doi: 10.1016/j.bmcl.2009.04.041. Epub 2009 Apr 18.
3
An efficient chemical approach to bispecific antibodies and antibodies of high valency.
Bioorg Med Chem Lett. 2009 Jul 15;19(14):3716-20. doi: 10.1016/j.bmcl.2009.05.047. Epub 2009 May 18.
4
A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy.
J Mol Biol. 2003 Sep 26;332(4):889-99. doi: 10.1016/s0022-2836(03)00992-6.
5
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs.
Nat Protoc. 2007;2(2):449-56. doi: 10.1038/nprot.2007.3.
7
A cofactor approach to copper-dependent catalytic antibodies.
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):2648-53. doi: 10.1073/pnas.052001099.
8
Enantioselective aldol cyclodehydrations catalyzed by antibody 38C2.
Org Lett. 1999 Jul 15;1(1):59-61. doi: 10.1021/ol9905405.
9
Chemically Programmed Bispecific Antibody Targeting Legumain Protease and αvβ3 Integrin Mediates Strong Antitumor Effects.
Mol Pharm. 2015 Jul 6;12(7):2544-50. doi: 10.1021/acs.molpharmaceut.5b00257. Epub 2015 Jun 9.
10
Aldol sensors for the rapid generation of tunable fluorescence by antibody catalysis.
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15351-5. doi: 10.1073/pnas.95.26.15351.

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Sculpting a Uniquely Reactive Cysteine Residue for Site-Specific Antibody Conjugation.
Bioconjug Chem. 2022 Jun 15;33(6):1192-1200. doi: 10.1021/acs.bioconjchem.2c00146. Epub 2022 May 18.
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Synthesis and Evaluation of a Non-Peptide Small-Molecule Drug Conjugate Targeting Integrin αβ.
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A new immunochemical strategy for triple-negative breast cancer therapy.
Sci Rep. 2021 Jul 21;11(1):14875. doi: 10.1038/s41598-021-94230-4.
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Site-Specific Antibody-Drug Conjugates in Triple Variable Domain Fab Format.
Biomolecules. 2020 May 14;10(5):764. doi: 10.3390/biom10050764.
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Chemically Programmable and Switchable CAR-T Therapy.
Angew Chem Int Ed Engl. 2020 Jul 13;59(29):12178-12185. doi: 10.1002/anie.202005432. Epub 2020 May 18.
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Conventional and Chemically Programmed Asymmetric Bispecific Antibodies Targeting Folate Receptor 1.
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Photoactivatable Fluorogenic Labeling via Turn-On "Click-Like" Nitroso-Diene Bioorthogonal Reaction.
Adv Sci (Weinh). 2019 May 2;6(13):1802039. doi: 10.1002/advs.201802039. eCollection 2019 Jul 3.
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Chemically Programmed Bispecific Antibody Targeting Legumain Protease and αvβ3 Integrin Mediates Strong Antitumor Effects.
Mol Pharm. 2015 Jul 6;12(7):2544-50. doi: 10.1021/acs.molpharmaceut.5b00257. Epub 2015 Jun 9.

本文引用的文献

1
Click chemistry, a powerful tool for pharmaceutical sciences.
Pharm Res. 2008 Oct;25(10):2216-30. doi: 10.1007/s11095-008-9616-1. Epub 2008 May 29.
3
Preparation of integrin alpha(v)beta3-targeting Ab 38C2 constructs.
Nat Protoc. 2007;2(2):449-56. doi: 10.1038/nprot.2007.3.
4
A comparative study of bioorthogonal reactions with azides.
ACS Chem Biol. 2006 Nov 21;1(10):644-8. doi: 10.1021/cb6003228.
5
Chemically programmed antibodies: endothelin receptor targeting CovX-Bodies.
Bioorg Med Chem Lett. 2007 Jan 15;17(2):501-6. doi: 10.1016/j.bmcl.2006.10.009. Epub 2006 Oct 7.
6
Breaking the one antibody-one target axiom.
Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11009-14. doi: 10.1073/pnas.0603822103. Epub 2006 Jul 5.
10
Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst.
Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5396-400. doi: 10.1073/pnas.0931308100. Epub 2003 Apr 17.

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