The response to lenalidomide of myelodysplastic syndrome patients with deletion del(5q) can be sequentially monitored in CD34+ progenitor cells.
作者信息
Mohr Brigitte, Oelschlaegel Uta, Thiede Christian, Stewart Michelle Meredyth, Ehninger Gerhard, Platzbecker Uwe
出版信息
Haematologica. 2009 Mar;94(3):430-1. doi: 10.3324/haematol.13865. Epub 2009 Jan 30.
Abstract
摘要
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The response to lenalidomide of myelodysplastic syndrome patients with deletion del(5q) can be sequentially monitored in CD34+ progenitor cells.伴有5号染色体长臂缺失（del(5q)）的骨髓增生异常综合征患者对来那度胺的反应可在CD34+祖细胞中进行连续监测。
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Unimpaired terminal erythroid differentiation and preserved enucleation capacity in myelodysplastic 5q(del) clones: a single cell study.骨髓增生异常综合征 5q(del)克隆中未受损的终末红细胞分化和保持去核能力：一项单细胞研究。
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本文引用的文献
1
Myelodysplastic syndrome with isolated 5q deletion (5q- syndrome). A clonal stem cell disorder characterized by defective ribosome biogenesis.伴有孤立性5q缺失的骨髓增生异常综合征（5q-综合征）。一种以核糖体生物合成缺陷为特征的克隆性干细胞疾病。
Haematologica. 2008 Jul;93(7):967-72. doi: 10.3324/haematol.13377.
2
Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion.来那度胺治疗伴有5号染色体长臂缺失的骨髓增生异常综合征
N Engl J Med. 2006 Oct 5;355(14):1456-65. doi: 10.1056/NEJMoa061292.
3
Efficacy of lenalidomide in myelodysplastic syndromes.来那度胺在骨髓增生异常综合征中的疗效。
N Engl J Med. 2005 Feb 10;352(6):549-57. doi: 10.1056/NEJMoa041668.
4
Detection of relapse by sequential monitoring of chimerism in circulating CD34+ cells.通过对循环CD34+细胞嵌合体进行序贯监测来检测复发。
Ann Hematol. 2002;81 Suppl 2:S27-8.
5
Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after allogeneic stem cell transplantation.白血病谱系特异性嵌合分析是急性髓系白血病和骨髓增生异常综合征患者异基因干细胞移植后复发的敏感预测指标。
Leukemia. 2001 Dec;15(12):1976-85. doi: 10.1038/sj.leu.2402311.
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