Determination of ampicillin in biological fluids by coupled-column liquid chromatography and post-column derivatization.
作者信息
Lanbeck-Vallén K, Carlqvist J, Nordgren T
机构信息
Department of Bioanalysis, Astra Research Centre AB, Södertälje, Sweden.
出版信息
J Chromatogr. 1991 Jun 14;567(1):121-8. doi: 10.1016/0378-4347(91)80316-5.
PMID:1918239
Abstract
A rapid and sensitive high-performance liquid chromatographic method has been developed for the determination of ampicillin in plasma and urine. The method involves a simple deproteinization step and separation on a coupled-column chromatographic system followed by post-column derivatization and fluorescence detection. The method has been used for the determination of ampicillin in various clinical studies. The high sensitivity makes it especially useful for small sample volumes, e.g. samples from pediatric patients.
摘要
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