Ieiri Ichiro, Higuchi Shun
Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Yakugaku Zasshi. 2009 Feb;129(2):231-5. doi: 10.1248/yakushi.129.231.
Intra- and inter-ethnic differences in pharmacokinetic and pharmacodynamic profiles of clinically relevant drugs are important issues not only for scenes of appropriate drug use in clinical settings but also for those of the drug development. Pharmacogenomics is extremely useful for understanding these racial differences. In this presentation, I will introduce pharmacogenomic concepts (e.g., single nucleotide polymorphisms (SNPs) and haplotype) for interpretation of racial differences in some drugs; pharmacogenomics of drug transporters such as OATP1B1 (organic anion transporting-polypeptide 1B1) and OCT1 (organic cation transporter 1) in pravastatin, metformin, and rosuvastatin will be discussed as model drugs.
临床相关药物的药代动力学和药效学特征的种族内和种族间差异不仅是临床环境中合理用药场景的重要问题，也是药物研发中的重要问题。药物基因组学对于理解这些种族差异极为有用。在本报告中，我将介绍用于解释某些药物种族差异的药物基因组学概念（如单核苷酸多态性（SNP）和单倍型）；将讨论普伐他汀、二甲双胍和瑞舒伐他汀等药物中药物转运体（如OATP1B1（有机阴离子转运多肽1B1）和OCT1（有机阳离子转运体1））的药物基因组学作为模型药物。
