Department of Ophthalmology, Centre for Eye Research Australia, University of Melbourne, East Melbourne, Victoria, Australia.
Eye (Lond). 2009 Dec;23(12):2194-9. doi: 10.1038/eye.2009.1.
To investigate the effect of topical prostaglandin analogue use on the efficacy of selective laser trabeculoplasty (SLT) intraocular pressure (IOP) lowering in patients with open-angle glaucoma.
This retrospective study included 123 consecutive patients who underwent 180 degrees SLT for the first time. Eyes were grouped into those that received prostaglandin analogues before and after SLT (n=74) and those that did not (n=49). The main outcome measure was IOP lowering after SLT. Success was defined as > or =20% reduction in IOP without further glaucoma intervention.
There was no significant difference in IOP lowering at 6 months post-laser between the prostaglandin and non-prostaglandin groups (3.9+/-4.8 vs 4.6+/-3.6 mm Hg, P=0.43). Long-term SLT success rates were also not significantly different between the treatment groups (Kaplan-Meier survival analysis, P=0.68). IOP lowering at 6 months was similar in eyes that received no glaucoma medications, monotherapy with or without a prostaglandin analogue, or combination therapy with or without prostaglandin analogues (P=0.81). Logistic regression analysis showed that various patient characteristics including age, sex, type of glaucoma, previous glaucoma surgery, and other glaucoma risk factors did not predict a successful SLT outcome. However, higher pre-operative IOP was found to predict SLT success (odds ratio=1.12, 95% CI=1.02-1.24, P=0.02).
The IOP lowering efficacy of SLT is not influenced by the use of topical prostaglandin analogues.
研究局部前列腺素类似物的使用对开角型青光眼患者选择性激光小梁成形术（SLT）降低眼压疗效的影响。
本回顾性研究纳入了 123 例首次接受 180 度 SLT 的连续患者。将眼睛分为 SLT 前后接受前列腺素类似物治疗的组（n=74）和未接受前列腺素类似物治疗的组（n=49）。主要观察指标为 SLT 后眼压降低。成功定义为眼压降低≥20%，无需进一步进行青光眼干预。
SLT 后 6 个月时，前列腺素组和非前列腺素组的眼压降低差异无统计学意义（3.9+/-4.8 比 4.6+/-3.6mmHg，P=0.43）。两组间长期 SLT 成功率也无显著差异（Kaplan-Meier 生存分析，P=0.68）。未使用任何青光眼药物、单一药物治疗（联合或不联合前列腺素类似物）或联合药物治疗（联合或不联合前列腺素类似物）的眼睛，6 个月时的眼压降低相似（P=0.81）。Logistic 回归分析显示，包括年龄、性别、青光眼类型、既往青光眼手术和其他青光眼危险因素在内的各种患者特征均不能预测 SLT 结局。然而，较高的术前眼压被发现可预测 SLT 成功（优势比=1.12，95%CI=1.02-1.24，P=0.02）。
SLT 的眼压降低疗效不受局部前列腺素类似物使用的影响。
