Allori Alexander C, Sailon Alexander M, Warren Stephen M
Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, New York, USA.
Tissue Eng Part B Rev. 2008 Sep;14(3):275-83. doi: 10.1089/ten.teb.2008.0083.
The bony biochemical environment is a complex system that permits and promotes cellular functions that lead to matrix production and ossification. In Part I of this review, we discussed the important actions of signaling molecules, including hormones, cytokines, and growth factors. Here, we review other constituents of the extracellular matrix, including minerals, fibrinous and nonfibrinous proteins, and enzymes such as the matrix metalloproteinases. We conclude with a discussion of the role of biochemical modulation in endogenous and exogenous tissue engineering.
骨生化环境是一个复杂的系统，它允许并促进导致基质产生和骨化的细胞功能。在本综述的第一部分，我们讨论了信号分子的重要作用，包括激素、细胞因子和生长因子。在这里，我们综述细胞外基质的其他成分，包括矿物质、纤维状和非纤维状蛋白质，以及诸如基质金属蛋白酶等酶。我们最后讨论生化调节在内源性和外源性组织工程中的作用。
