Laboratory of Ischemic and Neurodegenerative Brain Research, Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Neuropsychiatr Dis Treat. 2008 Oct;4(5):855-64. doi: 10.2147/ndt.s3739.
The development of neuronal death and amyloid plaques is a characteristic feature of ischemic- and Alzheimer-type dementia. An important aspect of neuronal loss and amyloid plaques are their topography and neuropathogenesis. This review was performed to present the hypothesis that different fragments of blood-borne amyloid precursor protein are able to enter the ischemic blood-brain barrier. Chronic disruption of the blood-brain barrier after ischemic injury was shown. As an effect of chronic ischemic blood-brain barrier injury, a visible connection of amyloid plaques with neurovasculature was observed. This neuropathology appears to have similar distribution and mechanisms to Alzheimer's disease. The usefulness of rival ischemic theory in elucidating the neuropathogenesis of amyloid plaques formation and neuronal death in Alzheimer's disorder is discussed.
神经元死亡和淀粉样斑块的发展是缺血性和阿尔茨海默型痴呆的特征。神经元丧失和淀粉样斑块的一个重要方面是它们的分布和神经发病机制。进行这项综述是为了提出这样一种假设，即血液来源的淀粉样前体蛋白的不同片段能够进入缺血性血脑屏障。研究表明，缺血性损伤后慢性血脑屏障破坏。作为慢性缺血性血脑屏障损伤的结果，观察到淀粉样斑块与神经脉管系统的明显连接。这种神经病理学似乎与阿尔茨海默病具有相似的分布和机制。讨论了竞争的缺血性理论在阐明阿尔茨海默病中淀粉样斑块形成和神经元死亡的神经发病机制中的有用性。
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