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Oddi 括约肌切开术是否适用于肝胆管结石?

Is Oddi sphincterotomy an indication for hepatolithiasis?

机构信息

Department of Surgery, Peking University Third Hospital, Beijing, 100191, People's Republic of China.

出版信息

Surg Endosc. 2009 Oct;23(10):2268-72. doi: 10.1007/s00464-008-0304-3. Epub 2009 Jan 28.

Abstract

BACKGROUND

The purpose of treatment for hepatolithiasis is reducing recurrent cholangitis. This study was designed to determine the long-term outcome of Oddi sphincterotomy for hepatolithiasis.

METHODS

Thirty-two consecutive hepatolithiasis patients, including 15 cases that had undergone conventional open surgical transduodenal sphincteroplasty (COSTS) and 17 cases with endoscopic sphincterotomy (EST), were followed up for a long term. We compared the post-treatment rates of recurrent cholangitis and acute cholangitis severe type (ACST) with the ones of pretreatment in each group, respectively. Paired chi(2) test was used.

RESULTS

In the COSTS group, neither the post-operative rate of recurrent cholangitis (86.7%, 13/15 vs. 100%, 15/15) nor ACST (26.7%, 4/15 vs. 46.7%, 7/15) decreased (p > 0.05) compared with before the operation. In the EST group, the situation was the same: neither the rate of post-EST recurrent cholangitis (76.5%, 13/17 vs. 82.4%, 14/17) nor ACST (29.4%, 5/17 vs. 23.5%, 4/17) were reduced significantly (p > 0.05).

CONCLUSIONS

Both eradication of hepatobiliary lesions and keeping Oddi sphincter intact should be emphasized in the management of hepatolithiasis. Neither COSTS nor EST is an effective method or can achieve the goal of reducing cholangitis for hepatolithiasis.

摘要

背景

治疗肝内胆管结石的目的是减少复发性胆管炎。本研究旨在确定Oddi 括约肌切开术治疗肝内胆管结石的长期疗效。

方法

对 32 例连续肝内胆管结石患者(其中 15 例行传统开腹经十二指肠Oddi 括约肌成形术(COSTS),17 例行内镜下括约肌切开术(EST))进行长期随访。分别比较两组患者治疗后复发性胆管炎和急性胆管炎重症型(ACST)的发生率与治疗前的差异。采用配对卡方检验。

结果

COSTS 组中,术后复发性胆管炎的发生率(86.7%,13/15 例比 100%,15/15 例)和 ACST 发生率(26.7%,4/15 例比 46.7%,7/15 例)均无明显下降(p>0.05)。EST 组的情况也相同:EST 后复发性胆管炎的发生率(76.5%,13/17 例比 82.4%,14/17 例)和 ACST 发生率(29.4%,5/17 例比 23.5%,4/17 例)均无明显下降(p>0.05)。

结论

肝内胆管结石的治疗既要强调消除肝胆病变,又要保持 Oddi 括约肌的完整。COSTS 和 EST 均不是治疗肝内胆管结石减少胆管炎的有效方法或手段。

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