白细胞整合素及其配体相互作用。
Leukocyte integrins and their ligand interactions.
机构信息
Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, NY 14642, USA.
出版信息
Immunol Res. 2009 Dec;45(2-3):195-208. doi: 10.1007/s12026-009-8101-1. Epub 2009 Jan 29.
Abstract
Although critical for cell adhesion and migration during normal immune-mediated reactions, leukocyte integrins are also involved in the pathogenesis of diverse clinical conditions including autoimmune diseases and chronic inflammation. Leukocyte integrins therefore have been targets for anti-adhesive therapies to treat the inflammatory disorders. Recently, the therapeutic potential of integrin antagonists has been demonstrated in psoriasis and multiple sclerosis. However, current therapeutics broadly affect integrin functions and, thus, yield unfavorable side effects. This review discusses the major leukocyte integrins and the anti-adhesion strategies for treating immune diseases.
摘要
虽然白细胞整合素对于正常免疫介导反应中的细胞黏附和迁移至关重要，但它们也参与了多种临床情况的发病机制，包括自身免疫性疾病和慢性炎症。因此，白细胞整合素已成为抗黏附治疗的靶点，以治疗炎症性疾病。最近，整合素拮抗剂在银屑病和多发性硬化症中的治疗潜力已经得到了证实。然而，目前的治疗方法广泛影响整合素的功能，因此产生了不利的副作用。本文讨论了主要的白细胞整合素以及治疗免疫疾病的抗黏附策略。
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