Lloyd S, Wijesundera M K, Soulsby E J
Department of Clinical Veterinary Medicine, University of Cambridge, U.K.
J Comp Pathol. 1991 Jul;105(1):93-104. doi: 10.1016/s0021-9975(08)80064-3.
Small intestinal histopathology and absorption were examined in Beagle puppies infected with either a moderate or a low burden of Toxocara canis. Infection with T. canis significantly reduced absorption of xylose, but only slightly delayed absorption of para-aminobenzoic acid. Fat assimilation was reduced and faecal proteolytic activity was increased. A significant reduction in villous height occurred and was inversely related to the extent of the infection. Villous goblet cell numbers, particularly those in the luminal third of the villus, were lowest and crypt goblet cell numbers were highest in the most heavily infected of the puppies. Villous goblet cell numbers increased rapidly after treatment of the puppies with piperazine or after the spontaneous elimination of the T. canis infection while crypt goblet cell numbers were less affected by elimination of the parasites. Intra-epithelial lymphocyte numbers were lowest in 33- to 37-day-old puppies infected with greater than 127 T. canis and highest in 44- to 46-day-old puppies losing their infection. Infection with T. canis had no apparent effect on mast cell numbers or pyroninophilic cell numbers in the lamina propria.
对感染中度或低度犬弓首蛔虫的比格幼犬的小肠组织病理学和吸收情况进行了检查。感染犬弓首蛔虫显著降低了木糖的吸收，但仅轻微延迟了对氨基苯甲酸的吸收。脂肪同化作用降低，粪便蛋白水解活性增加。绒毛高度显著降低，且与感染程度呈负相关。在感染最严重的幼犬中，绒毛杯状细胞数量，尤其是绒毛顶部三分之一处的数量最低，而隐窝杯状细胞数量最高。在用哌嗪治疗幼犬后或犬弓首蛔虫感染自然消除后，绒毛杯状细胞数量迅速增加，而隐窝杯状细胞数量受寄生虫消除的影响较小。感染超过127条犬弓首蛔虫的33至37日龄幼犬的上皮内淋巴细胞数量最低，而正在清除感染的44至46日龄幼犬的上皮内淋巴细胞数量最高。感染犬弓首蛔虫对固有层中的肥大细胞数量或嗜派洛宁细胞数量没有明显影响。
