Gerli Roberto, Nocentini Giuseppe, Alunno Alessia, Bocci Elena Bartoloni, Bianchini Rodolfo, Bistoni Onelia, Riccardi Carlo
Rheumatology Unit, Department of Clinical & Experimental Medicine, University of Perugia, Perugia, Italy.
Autoimmun Rev. 2009 Mar;8(5):426-30. doi: 10.1016/j.autrev.2009.01.004. Epub 2009 Feb 8.
The concept that regulatory T cells (Treg) play a key role in both development and maintenance of autoimmune response in rheumatic diseases is well accepted. In recent years, several studies analyzed Treg cell phenotype and function in systemic lupus erythematosus (SLE), the prototypical systemic autoimmune disorder in humans. Although qualitative and/or quantitative abnormalities of Treg cells have been shown, data are often conflicting. This may depend on the selection of patients with different degrees of disease activity or on immunosuppressive treatments that can alter Treg cell findings. Among several proposed surface or intracellular Treg cell markers, CD25 at high level of expression and the transcription factor Foxp3 are the two most investigated in SLE. Despite the glucocorticoid-induced TNF receptor-related protein (GITR) represents a reliable phenotypic marker of murine Treg cells, little is known about its role in humans, in particular in the course of systemic autoimmune disorders. Preliminary data seems to suggest that this marker may represent a good tool to identify cell populations included within Treg cell subsets.
调节性T细胞（Treg）在风湿性疾病自身免疫反应的发生和维持中起关键作用这一概念已被广泛接受。近年来，多项研究分析了系统性红斑狼疮（SLE）（人类典型的系统性自身免疫性疾病）中Treg细胞的表型和功能。尽管已显示Treg细胞存在定性和/或定量异常，但数据往往相互矛盾。这可能取决于对不同疾病活动程度患者的选择，或取决于可改变Treg细胞研究结果的免疫抑制治疗。在几种提出的表面或细胞内Treg细胞标志物中，高表达水平的CD25和转录因子Foxp3是SLE中研究最多的两个。尽管糖皮质激素诱导的TNF受体相关蛋白（GITR）是小鼠Treg细胞可靠的表型标志物，但对其在人类中的作用，尤其是在系统性自身免疫性疾病过程中的作用了解甚少。初步数据似乎表明，该标志物可能是识别Treg细胞亚群中包含的细胞群体的良好工具。
