Dohan Ehrenfest David M, Rasmusson Lars, Albrektsson Tomas
Department of Biomaterials, Institute of Clinical Sciences, The Sahlgrenska Academy at University of Gothenburg, Sweden.
Trends Biotechnol. 2009 Mar;27(3):158-67. doi: 10.1016/j.tibtech.2008.11.009. Epub 2009 Jan 31.
The topical use of platelet concentrates is recent and its efficiency remains controversial. Several techniques for platelet concentrates are available; however, their applications have been confusing because each method leads to a different product with different biology and potential uses. Here, we present classification of the different platelet concentrates into four categories, depending on their leucocyte and fibrin content: pure platelet-rich plasma (P-PRP), such as cell separator PRP, Vivostat PRF or Anitua's PRGF; leucocyte- and platelet-rich plasma (L-PRP), such as Curasan, Regen, Plateltex, SmartPReP, PCCS, Magellan or GPS PRP; pure plaletet-rich fibrin (P-PRF), such as Fibrinet; and leucocyte- and platelet-rich fibrin (L-PRF), such as Choukroun's PRF. This classification should help to elucidate successes and failures that have occurred so far, as well as providing an objective approach for the further development of these techniques.
血小板浓缩物的局部应用是最近才出现的,其有效性仍存在争议。有几种制备血小板浓缩物的技术;然而,它们的应用一直令人困惑,因为每种方法都会产生具有不同生物学特性和潜在用途的不同产品。在此,我们根据白细胞和纤维蛋白含量将不同的血小板浓缩物分为四类:纯富血小板血浆(P-PRP),如血细胞分离机采集的PRP、Vivostat PRF或阿尼图的PRGF;富含白细胞和血小板的血浆(L-PRP),如Curasan、Regen、Plateltex、SmartPReP、PCCS、Magellan或GPS PRP;纯富血小板纤维蛋白(P-PRF),如Fibrinet;以及富含白细胞和血小板的纤维蛋白(L-PRF),如舒克鲁恩PRF。这种分类应有助于阐明迄今为止所取得的成功与失败,以及为这些技术的进一步发展提供一种客观的方法。