Leitner G C, Gruber R, Neumüller J, Wagner A, Kloimstein P, Höcker P, Körmöczi G F, Buchta C
Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Vienna, Austria.
Vox Sang. 2006 Aug;91(2):135-9. doi: 10.1111/j.1423-0410.2006.00815.x.
Different systems for preparation of platelet-rich plasma are commercially available, but data for comparison of these systems have not been published so far.
We investigated the performance of Vivostat PRF Preparation Kit, PCCS Platelet Concentrate Collection System, Harvest SmartPReP 2 APC 60 Process, and Fibrinet Autologous Fibrin & Platelet System. The preparations provided by these systems are platelet concentrates with high numbers of platelets in a small volume of plasma and PDGF-AB is released continuously during the 5 days after preparation.
Vivostat PRF Preparation Kit, PCCS Platelet Concentrate Collection System, Harvest SmartPReP 2 APC 60 Process are comparable in platelet yield and total amount of released PDGF-AB after 120 h while with Fibrinet the lowest platelet yield and PDGF-AB content of supernatant was achieved. The ability of growth factor release was equal in all four systems.
In conclusion, all four systems for preparation of platelet-rich plasma investigated result in considerable growth factor release. In what extent the total content of PDGF-AB as a consequence of platelet yield has an impact on wound healing has to be further investigated.
目前市场上有不同的富血小板血浆制备系统，但尚未有关于这些系统比较的数据发表。
我们研究了Vivostat PRF制备试剂盒、PCCS血小板浓缩物采集系统、Harvest SmartPReP 2 APC 60工艺和Fibrinet自体纤维蛋白和血小板系统的性能。这些系统提供的制剂是在少量血浆中含有大量血小板的血小板浓缩物，并且在制备后的5天内持续释放血小板衍生生长因子-AB（PDGF-AB）。
Vivostat PRF制备试剂盒、PCCS血小板浓缩物采集系统、Harvest SmartPReP 2 APC 60工艺在120小时后的血小板产量和释放的PDGF-AB总量方面具有可比性，而Fibrinet的血小板产量最低，上清液中的PDGF-AB含量也最低。所有四个系统中生长因子的释放能力相同。
总之，所研究的所有四种富血小板血浆制备系统均能释放大量生长因子。血小板产量导致的PDGF-AB总含量在多大程度上影响伤口愈合有待进一步研究。
