Hughes K J, McGorum B C, Love S, Dixon P M
Division of Companion Animal Sciences, University of Glasgow, Glasgow G61 1QH, UK.
Vet Rec. 2009 Jan 31;164(5):142-7. doi: 10.1136/vr.164.5.142.
Six ponies and four horses with a mean (sd) age of 15.9 (6.0) years developed sudden-onset bilateral laryngeal paralysis (BLP) in association with hepatic dysfunction. Nine of them had been referred for the investigation of respiratory distress, and one pony had been referred for weight loss before BLP developed. Nine of the animals had clinicopathological evidence of liver disease, and nine had histological evidence of liver disease. All of the animals had one or more of the following: hepatic encephalopathy (in eight), hyperammonaemia (in six) and endoscopic evidence of BLP (in nine). Three of the animals had signs of pituitary pars intermedia dysfunction, a diagnosis supported in two by endocrine function testing, and in two by histopathological examination. Histopathological examination of the intrinsic laryngeal musculature and recurrent laryngeal nerves of four of the horses and of the region of the nucleus ambiguus of two did not reveal any abnormalities. Three of the animals were euthanased after they had first been examined, and one improved temporarily before the condition recurred. A temporary tracheostomy was performed in six of the animals, five of which subsequently died or were euthanased; one pony recovered.
6匹矮种马和4匹马，平均（标准差）年龄为15.9（6.0）岁，出现了与肝功能障碍相关的突发性双侧喉麻痹（BLP）。其中9匹因呼吸窘迫被转诊进行检查，1匹矮种马在BLP出现前因体重减轻被转诊。9只动物有肝病的临床病理证据，9只动物有肝病的组织学证据。所有动物都有以下一种或多种情况：肝性脑病（8只）、高氨血症（6只）和内镜下BLP证据（9只）。3只动物有垂体中间叶功能障碍的体征，其中2只通过内分泌功能测试得到支持，2只通过组织病理学检查得到支持。对4匹马的喉内肌和喉返神经以及2匹马的疑核区域进行组织病理学检查，未发现任何异常。3只动物在首次检查后实施了安乐死，1只在病情复发前暂时有所好转。6只动物进行了临时气管切开术，其中5只随后死亡或实施了安乐死；1匹矮种马康复。
