Tada T, Ohkubo I, Niwa M, Sasaki M, Tateyama H, Eimoto T
Department of Pathology, Nagoya City University Medical School, Japan.
J Histochem Cytochem. 1991 Sep;39(9):1221-6. doi: 10.1177/39.9.1918940.
The Zn-alpha 2-glycoprotein (Zn-alpha 2-GP) is present at a high concentration in the seminal plasma and at significant levels in other human body fluids. Its precise localization, however, has remained unclear, as well as its physiological and pathological significance. The present study reports the immunohistochemical localization of this protein in normal adult human tissues. Localization of the reactive product to anti-human plasma Zn-alpha 2-GP antibody was demonstrated in the following cells: luminal and basal cells of the prostate gland, luminal epithelial cells of the acini and of some ducts of the mammary glands, luminal cells of the secretory portion of the eccrine and apocrine sweat glands, serous cells of the salivary, tracheal, and bronchial glands, acinar cells of the esophageal glands, exocrine acinar cells of the pancreas, hepatocytes of the liver, and epithelial cells of the proximal and distal tubules in the kidney. The present results suggest that Zn-alpha 2-GP exerts some unknown but fairly widespread exocrine function and may be produced in the various epithelial cells tested. Hepatocytes are also suggested to be a source of the protein in the blood plasma.
锌α2糖蛋白（Zn-α2-GP）在精浆中浓度很高，在其他人体体液中也有显著水平。然而，其确切定位以及生理和病理意义仍不清楚。本研究报告了该蛋白在正常成人组织中的免疫组化定位。抗人血浆Zn-α2-GP抗体的反应产物在以下细胞中被证实有定位：前列腺的管腔细胞和基底细胞、乳腺腺泡及部分导管的管腔上皮细胞、外分泌汗腺和顶泌汗腺分泌部的管腔细胞、唾液腺、气管腺和支气管腺的浆液细胞、食管腺的腺泡细胞、胰腺的外分泌腺泡细胞、肝脏的肝细胞以及肾脏近端和远端小管的上皮细胞。目前的结果表明，Zn-α2-GP发挥着一些未知但相当广泛的外分泌功能，可能在测试的各种上皮细胞中产生。肝细胞也被认为是血浆中该蛋白的来源。
