血液透析患者脉搏波速度与液体分布的相关性

Correlation between pulse wave velocity and fluid distribution in hemodialysis patients.

作者信息

Zheng Danxia, Cheng Li-Tao, Zhuang Zhen, Gu Yue, Tang Li-Jun, Wang Tao

机构信息

Division of Nephrology, Peking University Third Hospital, Beijing, PR China.

出版信息

Blood Purif. 2009;27(3):248-52. doi: 10.1159/000199432. Epub 2009 Feb 4.

DOI:10.1159/000199432

PMID:19190400

Abstract

BACKGROUND

In this study, we focused on whether volume overload plays a role in the development of arterial stiffness.

METHODS

Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was assessed by bioimpedance analysis.

RESULTS

Patients were divided into a high PWV group and a low PWV group based on the median of PWV. Age, systolic blood pressure, pulse pressure (PP), extracellular water/total body water ratio (ECW/TBW), diabetic status (all p < 0.01), and history of cardiac events (p < 0.05) were significantly higher in the high PWV group (n = 37) than in the low PWV group. In the correlation analysis, PWV was positively associated with PP, systolic blood pressure, ECW/TBW, age, history of cardiac events, and diabetes (all p < 0.01). Multiple regression analysis showed that PWV was independently related to PP and ECW/TBW (p < 0.01).

CONCLUSION

Volume overload plays an important role in the development of arterial stiffness in hemodialysis patients.

摘要

背景

在本研究中，我们重点关注容量超负荷是否在动脉僵硬度的发展中起作用。

方法

73例维持性血液透析患者纳入一项横断面研究。通过颈股脉搏波速度（PWV）评估动脉僵硬度，通过生物电阻抗分析评估容量超负荷。

结果

根据PWV的中位数将患者分为高PWV组和低PWV组。高PWV组（n = 37）的年龄、收缩压、脉压（PP）、细胞外液/总体液比值（ECW/TBW）、糖尿病状态（所有p < 0.01）和心脏事件史（p < 0.05）均显著高于低PWV组。在相关性分析中，PWV与PP、收缩压、ECW/TBW、年龄、心脏事件史和糖尿病呈正相关（所有p < 0.01）。多元回归分析显示，PWV与PP和ECW/TBW独立相关（p < 0.01）。