De Grüneck J M, Naef A P, Baumann R P
Schweiz Med Wochenschr. 1977 Feb 26;107(8):259-66.
Twenty-four patients with bronchial adenoma seen over a 20-year period are reviewed. Follow-up data was available in all patients. They included 19 with carcinoid, 2 with adenoid-cystic carcinoma, and 3 with muco-epidermoid carcinoma. Recurrent pulmonary infection, cough and hemoptysis were the most common clinical manifestations. Surgical resection was performed in all but one patient, who was treated by irradiation; bronchoplastic and conservative resectional procedures were used in 5 patients with carcinoid adenoma. Carcinoid tumors are considered to be very slowly-growing malignant neoplasms that sometimes give rise to metastases to regional lymph nodes. Such metastases were present in only one patient. All patients are alive and well. Adenoid-cystic carcinoma is a more aggressive tumor with a tendency to recur. Much of the difficulty in its treatment is due to its close proximity to the bifurcation of the trachea. One patient was operated upon three times for local recurrences and ultimately died from respiratory failure after the third operation. The other patient received radiation therapy with cobalt and is well, without recurrence, 3 years after the treatment. The 3 muco-epidermoid carcinomas were histologically similar to such tumors of salivary glands but behaved clinically like highly malignant tumors, no patients surviving 8 months after resection. The term bronchial adenoma is a misnomer. The neoplasms grouped under this heading should be called carcinoid adenoma, adenoid-cystic carcinoma, and muco-epidermoid carcinoma and considered as separate entities, since the ultimate course and prognosis is definitely different.
回顾了20年间收治的24例支气管腺瘤患者。所有患者均有随访数据。其中类癌19例,腺样囊性癌2例,黏液表皮样癌3例。反复肺部感染、咳嗽和咯血是最常见的临床表现。除1例接受放疗的患者外,其余均行手术切除;5例类癌腺瘤患者采用了支气管成形术和保守性切除术。类癌肿瘤被认为是生长非常缓慢的恶性肿瘤,有时会转移至区域淋巴结。仅1例患者出现此类转移。所有患者均存活且状况良好。腺样囊性癌是一种侵袭性更强的肿瘤,有复发倾向。其治疗的许多困难在于它紧邻气管分叉处。1例患者因局部复发接受了3次手术,最终在第三次手术后死于呼吸衰竭。另1例患者接受了钴放疗,治疗3年后状况良好,无复发。3例黏液表皮样癌在组织学上与唾液腺的此类肿瘤相似,但临床表现为高度恶性肿瘤,切除后无患者存活超过8个月。支气管腺瘤这一术语是用词不当。归入这一标题下的肿瘤应称为类癌腺瘤、腺样囊性癌和黏液表皮样癌,并被视为不同的实体,因为其最终病程和预后肯定不同。