Skvara Hans, Duschek Nikolaus, Karlhofer Franz
Department of Dermatology, Division of Immunodermatology and Infectious Skin Diseases, Medical University of Vienna, Austria.
J Dtsch Dermatol Ges. 2009 Jul;7(7):616-9. doi: 10.1111/j.1610-0387.2009.07040.x. Epub 2009 Feb 2.
A woman with oculocutaneous Behçet disease developed primary tuberculosis while being treated with infliximab. A latent tuberculosis infection had been excluded before therapy. After more than 80 weeks of treatment, the patient complained of fevers, night sweats, shivering and vigorous cough. The chest x-ray showed miliary shadowing. Mycobacterium tuberculosis was identified. The history revealed recent contact to an individual with smear-positive tuberculosis. This constellation speaks in favor of a de novo tuberculosis infection with a fulminant course.
一名患有眼皮肤型白塞病的女性在接受英夫利昔单抗治疗时发生了原发性肺结核。治疗前已排除潜伏性结核感染。经过80多个星期的治疗后，患者出现发热、盗汗、寒战和剧烈咳嗽。胸部X光显示粟粒状阴影。鉴定出结核分枝杆菌。病史显示患者近期与一名涂片阳性肺结核患者有接触。这种情况提示为新发的暴发性结核感染。
