Beccastrini E, Squatrito D, Emmi G, Fabbri P, Emmi L
Dermatol Online J. 2010 Sep 15;16(9):15.
Infliximab, a chimeric monoclonal anti-TNF-alfa agent used to treat autoimmune diseases, has shown a paradoxical side effect in the development of autoimmunity. We describe a case of alopecia areata universalis associated with infliximab treatment in a patient with Behçet disease. This case suggests a complex and contradictory role of TNF-α in the pathogenesis of alopecia areata.
英夫利昔单抗是一种用于治疗自身免疫性疾病的嵌合单克隆抗TNF-α药物，它在自身免疫性疾病的发展过程中显示出一种矛盾的副作用。我们描述了一例白塞病患者在接受英夫利昔单抗治疗后出现全秃的病例。该病例提示TNF-α在斑秃发病机制中具有复杂且矛盾的作用。
