Gregory Alice M, Caspi Avshalom, Moffitt Terrie E, Milne Barry J, Poulton Richie, Sears Malcolm R
Psychology Department, Goldsmiths College, University of London, Lewisham Way, New Cross, London, SE14 6NW.
J Pers. 2009 Apr;77(2):347-62. doi: 10.1111/j.1467-6494.2008.00550.x. Epub 2009 Feb 2.
The objective of the study was to examine the link between anxiety and allergies to establish whether it reflects a psychobiological reality or a possible methodological bias. A cohort of 1,037 children enrolled in the study. Anxiety disorders were assessed between 11 and 21 years. Anxious personality was assessed at 18 years. Allergies were examined at 21 years by (a) self reports, (b) skin pricks, and (c) serum total immunoglobulin E (IgE). Self-reported allergies were predicted by recurrent anxiety disorders (OR [95% CI]=1.56 [1.06-2.30], p=.023) and self-reports of anxious personality (OR [95% CI]=1.67 [1.17-2.37], p=.004): Objectively verified allergies were not. These results suggest that the link between anxiety and allergies may reflect a methodological artifact rather than a psychobiological reality.
该研究的目的是检验焦虑与过敏之间的联系，以确定这是反映了一种心理生物学现实还是可能存在的方法学偏差。1037名儿童参与了该研究。在11至21岁之间评估焦虑症。在18岁时评估焦虑人格。在21岁时通过以下方式检查过敏情况：（a）自我报告，（b）皮肤点刺试验，以及（c）血清总免疫球蛋白E（IgE）。复发性焦虑症（比值比[95%置信区间]=1.56[1.06 - 2.30]，p = 0.023）和焦虑人格的自我报告（比值比[95%置信区间]=1.67[1.17 - 2.37]，p = 0.004）可预测自我报告的过敏情况；但客观证实的过敏情况并非如此。这些结果表明，焦虑与过敏之间的联系可能反映的是一种方法学假象，而非心理生物学现实。
