Wynn P C, Stuart M C, Wallace A L, Kirby A C, Annison E F
Department of Animal Science, Sydney University, Camden, New South Wales, Australia.
J Endocrinol. 1991 Aug;130(2):313-20. doi: 10.1677/joe.0.1300313.
The effect of daily administration of ovine GH for a period of 4 weeks on somatomedin-C biological activity in plasma was investigated in mature Merino sheep fed a maintenance energy intake (low plane; LP) or 1.6 times this amount (high plane; HP). The GH treatment resulted in a significant (P less than 0.05) increase in plasma GH levels in blood samples collected 23.5 h after each daily injection in both LP and HP groups. Plasma concentrations of somatomedin-C activity and insulin were significantly stimulated to a maximum level by the third GH injection and remained at this level for 7 days. Subsequently, circulating levels of both hormones fell to 40-50% of the peak response to GH and returned to basal levels within 48 h of the cessation of GH injections. In the HP group the response of plasma insulin and somatomedin-C activity to GH injection was greater than in the LP group.
研究了对维持能量摄入量（低水平；LP）或该摄入量1.6倍（高水平；HP）的成年美利奴绵羊每日注射绵羊生长激素4周对血浆中生长调节素C生物活性的影响。在LP组和HP组中，每次每日注射后23.5小时采集的血样中，生长激素处理均导致血浆生长激素水平显著升高（P<0.05）。生长激素注射第三次时，血浆中生长调节素C活性和胰岛素的浓度被显著刺激至最高水平，并在该水平维持7天。随后，两种激素的循环水平降至生长激素峰值反应的40 - 50%，并在生长激素注射停止后48小时内恢复到基础水平。在HP组中，血浆胰岛素和生长调节素C活性对生长激素注射的反应大于LP组。
