肌萎缩侧索硬化症患者血清中单克隆免疫球蛋白的定量分析。
Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis.
作者信息
Duarte F, Binet S, Lacomblez L, Bouche P, Preud'homme J L, Meininger V
机构信息
Laboratoire d'Immunologie et d'Immunopathologie, UA 1172 CNRS, Hôpital de la Milétrie, Poitiers, France.
出版信息
J Neurol Sci. 1991 Jul;104(1):88-91. doi: 10.1016/0022-510x(91)90220-2.
In a prospective study, we analysed the presence of monoclonal immunoglobulin (moIg) in the serum from 30 patients with amyotrophic lateral sclerosis (ALS) and 30 matched controls using a sensitive Western blot technique. The incidence of serum moIg was 60% in the ALS group and 13.3% in the control group. Most ALS sera contained 2 or 3 monoclonal components. They were IgG (72.7%) and IgM (27.3%). These results corroborate the concept of a probable association between ALS and serum moIg.
在一项前瞻性研究中，我们使用灵敏的蛋白质印迹技术分析了30例肌萎缩侧索硬化症（ALS）患者和30例匹配对照者血清中的单克隆免疫球蛋白（moIg）。ALS组血清moIg的发生率为60%，对照组为13.3%。大多数ALS患者血清含有2种或3种单克隆成分。它们是IgG（72.7%）和IgM（27.3%）。这些结果证实了ALS与血清moIg之间可能存在关联的概念。
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