新生儿时期幽门螺杆菌感染的来源。

The source of Helicobacter pylori infection in the neonatal period.

机构信息

Neonatology Unit, University of Bari, Italy.

出版信息

J Perinat Med. 2009;37(3):288-92. doi: 10.1515/JPM.2009.045.

DOI:10.1515/JPM.2009.045

PMID:19196211

Abstract

AIMS

To investigate the transmission of Helicobacter pylori in the perinatal period.

METHODS

H. pylori status of 180 women was preliminarily screened by serology and stool antigen test (SAT) within the fourth day after delivery and a positive value was confirmed by (13)C-urea breath test. Infants were analyzed by SAT at 1, 6, 12 and 18 months of age. H. pylori status was also investigated in the medical and paramedical staff of the Neonatology Unit.

RESULTS

H. pylori infection was found in 34.4% of the women. At the 1(st) month of age, 5 out of 172 newborns (2.9%) were H. pylori positive by SAT. Three out of the five positive infants were born to H. pylori non-infected mothers. Formula feeding (P=0.02) and admission in intermediate-risk neonatal unit (P=0.01) were significantly related to a positive H. pylori result. Medical and paramedical staff of the neonatology unit was found H. pylori positive in 34.8% of cases. All five H. pylori positive children spontaneously cleared the infection.

CONCLUSIONS

Perinatal H. pylori SAT positive status is low in our area, and it may be found both in infants from infected or non-infected mothers. Formula feeding and admission in intermediate-risk neonatal unit appear to be related with H. pylori infection.

摘要

目的

研究围产期幽门螺杆菌的传播。

方法

分娩后第 4 天通过血清学和粪便抗原检测（SAT）对 180 名女性进行 H. pylori 初步筛查，阳性值通过（13）C-尿素呼气试验确认。婴儿在 1、6、12 和 18 个月时通过 SAT 进行分析。还对新生儿科医护人员的 H. pylori 状况进行了调查。

结果

34.4%的女性存在 H. pylori 感染。在 1 个月时，172 名新生儿中有 5 名（2.9%）SAT 阳性。其中 3 名阳性婴儿的母亲没有 H. pylori 感染。配方奶喂养（P=0.02）和中危新生儿单元入院（P=0.01）与 H. pylori 阳性结果显著相关。新生儿科医护人员中发现 H. pylori 阳性率为 34.8%。所有 5 名 H. pylori 阳性儿童均自发清除了感染。