幽门螺杆菌感染的源头——母亲
The mother as source of Helicobacter pylori infection.
作者信息
Weyermann Maria, Adler Guido, Brenner Hermann, Rothenbacher Dietrich
机构信息
Department of Epidemiology, The German Centre for Research on Ageing, Heidelberg, Germany.
出版信息
Epidemiology. 2006 May;17(3):332-4. doi: 10.1097/01.ede.0000201257.31155.a0.
BACKGROUND
To further elucidate the intrafamilial transmission of Helicobacter pylori infection, we investigated the occurrence of infection by parental infection status in a large community-based birth cohort of children from Germany.
METHODS
Parental infection (at birth) and children's infection (at age 3 years) were determined by C-urea breath test and by monoclonal antigen stool test.
RESULTS
Twenty of 834 children (2.4%) were found to be infected. The odds ratio for H. pylori infection of the child was 12.9 (95% confidence interval = 3.2-52.5) if the mother was infected and 1.4 (0.4-4.6) if the father was infected, after adjustment for infection status of the other parent and for nationality. The number of older siblings was not a risk factor for H. pylori infection of the child.
CONCLUSIONS
This longitudinal study suggests that infected mothers are the main source of H. pylori infection of their children.
背景
为进一步阐明幽门螺杆菌感染的家庭内传播情况，我们在德国一个基于社区的大型儿童出生队列中，根据父母的感染状况调查了感染的发生情况。
方法
通过C - 尿素呼气试验和单克隆抗原粪便试验确定父母（出生时）和儿童（3岁时）的感染情况。
结果
834名儿童中有20名（2.4%）被发现感染。在对另一方父母的感染状况和国籍进行调整后，若母亲感染，儿童感染幽门螺杆菌的比值比为12.9（95%置信区间 = 3.2 - 52.5）；若父亲感染，比值比为1.4（0.4 - 4.6）。年长兄弟姐妹的数量不是儿童感染幽门螺杆菌的危险因素。
结论
这项纵向研究表明，感染的母亲是其子女幽门螺杆菌感染的主要来源。
Zotero 插件