Palmeri S, Gebbia V, Russo A, Gebbia N, Meli M, Rausa L
Sezione di Oncologia Clinica, Università di Palermo, Italy.
J Chemother. 1991 Jun;3(3):176-9. doi: 10.1080/1120009x.1991.11739088.
Twenty consecutive patients with advanced breast cancer were treated with a combination of cyclophosphamide 600 mg/m2 i.v. on day 1, epidoxorubicin 75 mg/m2 on day 1, and 5-fluorouracil 375 mg/m2 i.v. with folinic acid 200 mg/m2 i.v. on days 1----3. The overall response rate was 60%, with 10% of patients showing a complete response with a mean duration of 11.1 + months, and 50% of patients a partial response of 7.4 + months. A stabilization of 5.2 + months was obtained in 20% of cases, while 20% of patients progressed. The most frequently observed toxicity was leukopenia, while expected mucosal toxicities were rather mild.
连续20例晚期乳腺癌患者接受如下联合治疗：第1天静脉注射环磷酰胺600mg/m²，第1天静脉注射表柔比星75mg/m²，第1至3天静脉注射5-氟尿嘧啶375mg/m²及亚叶酸钙200mg/m²。总缓解率为60%，其中10%的患者完全缓解，平均缓解持续时间为11.1 + 个月，50%的患者部分缓解，缓解持续时间为7.4 + 个月。20%的病例病情稳定5.2 + 个月，20%的患者病情进展。最常观察到的毒性是白细胞减少，而预期的黏膜毒性相当轻微。
