Zaniboni A, Marpicati P, Simoncini E, Montini E, Meriggi F, Arcangeli G, Bonera F, Braga M, Ragni F, Marini G
Servizio di Oncologia, III Medicina, Spedali Civili, Brescia, Italy.
J Chemother. 1991 Jun;3(3):180-2. doi: 10.1080/1120009x.1991.11739089.
Twenty-six patients with advanced colorectal cancer were treated with a combination based on multimodal biochemical modulation of 5-fluorouracil by means of high dose folinic acid, low-dose alpha-2b interferon and dipyridamole. The overall response rate was 42% (95% confidence intervals = 23%. 61%) with four complete remissions (15%). The median duration of response was 9 months and the median survival for responders was 15 months (all patients = 12 months). Toxic side effects included oral mucositis (grade III-IV = 38%) and a generally mild flu-like syndrome. This regimen seems active and safe enough to be compared with the combination of fluorouracil and high-dose folinic acid.
26例晚期结直肠癌患者接受了基于大剂量亚叶酸、低剂量α-2b干扰素和双嘧达莫对5-氟尿嘧啶进行多模式生化调节的联合治疗。总缓解率为42%（95%置信区间=23%，61%），4例完全缓解（15%）。缓解持续时间中位数为9个月，缓解者的中位生存期为15个月（所有患者=12个月）。毒性副作用包括口腔黏膜炎（Ⅲ-Ⅳ级=38%）和一般轻度的流感样综合征。该方案似乎足够有效和安全，可与氟尿嘧啶和大剂量亚叶酸的联合方案相比较。
