Bacci G, Ferraro A, Casadei R, Barbieri E, Avella M, Ferrari S, Bertoni F, Picci P, Ruggieri P, Biagini R
Bone Tumor Center-Istituto Rizzoli, Bologna, Italy.
J Chemother. 1991 Jun;3(3):189-93. doi: 10.1080/1120009x.1991.11739091.
Primary lymphoma of bone (PLB) is an unusual but well-recognized extranodal presentation of non-Hodgkin's lymphoma. In most series treatment with radiotherapy alone results in a cure rate of approximately 40%. Between January 1972 and December 1982, 26 patients with biopsy proven PLB were treated at the Rizzoli Institute with radiotherapy (4000-5,500 rad) and chemotherapy (vincristine, cyclophosphamide and adriamycin). The minimal clinical staging included complete blood cell counts and serum chemistries, bone radiography, full lung tomography, isotope bone scan, bone marrow biopsy and bipedal lymphoangiograms. At a median follow-up of 13 years (8.5-18.5) there were only three relapses (2 cases of meningeal involvement and 1 recurrence in another bone). No local recurrences nor second tumor in the irradiated field were observed. We conclude that the addition of chemotherapy to radiotherapy results in an excellent cure rate for patients with PLB.
原发性骨淋巴瘤（PLB）是一种罕见但已得到充分认识的非霍奇金淋巴瘤的结外表现形式。在大多数病例系列中，单纯放疗的治愈率约为40%。1972年1月至1982年12月期间，26例经活检证实为PLB的患者在里佐利研究所接受了放疗（4000 - 5500拉德）和化疗（长春新碱、环磷酰胺和阿霉素）。最低限度的临床分期包括全血细胞计数和血清化学检查、骨骼X线摄影、全肺断层扫描、同位素骨扫描、骨髓活检和双侧淋巴血管造影。在中位随访13年（8.5 - 18.5年）时，仅有3例复发（2例脑膜受累，1例在另一处骨骼复发）。未观察到局部复发或放疗区域出现第二肿瘤。我们得出结论，放疗联合化疗可使PLB患者获得极高的治愈率。
