Burnier Laurent, Fontana Pierre, Angelillo-Scherrer Anne, Kwak Brenda R
Department of Internal Medicine, Division of Cardiology, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Physiology (Bethesda). 2009 Feb;24:36-44. doi: 10.1152/physiol.00036.2008.
Cell-to-cell communication is a process necessary for physiological tissue homeostasis and appears often altered during disease. Gap junction channels, formed by connexins, allow the direct intercellular communication between adjacent cells. After a brief review of the pathophysiology of atherosclerosis, we will discuss the role of connexins throughout the different stages of the disease.
细胞间通讯是生理组织稳态所必需的过程，在疾病期间常常发生改变。由连接蛋白形成的间隙连接通道允许相邻细胞之间进行直接的细胞间通讯。在简要回顾动脉粥样硬化的病理生理学之后，我们将讨论连接蛋白在该疾病不同阶段中的作用。
