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本文引用的文献

1
Risk of breast cancer and gynecologic cancers in a large population of nearly 50,000 infertile Danish women.近50000名丹麦不孕女性的乳腺癌和妇科癌症风险
Am J Epidemiol. 2008 Jul 1;168(1):49-57. doi: 10.1093/aje/kwn094. Epub 2008 Apr 29.
2
Malignant melanoma risk after exposure to fertility drugs: results from a large Danish cohort study.接触生育药物后的恶性黑色素瘤风险：一项大型丹麦队列研究的结果
Cancer Causes Control. 2008 Sep;19(7):759-65. doi: 10.1007/s10552-008-9138-5. Epub 2008 Mar 14.
3
Risk of thyroid cancer after exposure to fertility drugs: results from a large Danish cohort study.接触生育药物后患甲状腺癌的风险：一项丹麦大型队列研究的结果
Hum Reprod. 2008 Feb;23(2):451-6. doi: 10.1093/humrep/dem381. Epub 2007 Dec 6.
4
Risk of breast cancer after exposure to fertility drugs: results from a large Danish cohort study.接触生育药物后患乳腺癌的风险：丹麦一项大型队列研究的结果
Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1400-7. doi: 10.1158/1055-9965.EPI-07-0075. Epub 2007 Jun 21.
5
Different risk factor profiles for mucinous and nonmucinous ovarian cancer: results from the Danish MALOVA study.黏液性和非黏液性卵巢癌的不同风险因素特征：丹麦MALOVA研究结果
Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1160-6. doi: 10.1158/1055-9965.EPI-07-0089.
6
Uterine cancer after use of clomiphene citrate to induce ovulation.使用枸橼酸氯米芬诱导排卵后发生的子宫癌。
Am J Epidemiol. 2005 Apr 1;161(7):607-15. doi: 10.1093/aje/kwi084.
7
Ovulation induction and cancer risk.诱导排卵与癌症风险
Fertil Steril. 2005 Feb;83(2):261-74; quiz 525-6. doi: 10.1016/j.fertnstert.2004.09.016.
8
Histologic types of epithelial ovarian cancer: have they different risk factors?上皮性卵巢癌的组织学类型：它们有不同的风险因素吗？
Gynecol Oncol. 2005 Feb;96(2):520-30. doi: 10.1016/j.ygyno.2004.10.037.
9
A case-control study of ovarian cancer in relation to infertility and the use of ovulation-inducing drugs.一项关于卵巢癌与不孕及使用促排卵药物关系的病例对照研究。
Am J Epidemiol. 2004 Dec 1;160(11):1070-8. doi: 10.1093/aje/kwh315.
10
Ovarian cancer risk associated with varying causes of infertility.与不同不孕原因相关的卵巢癌风险。
Fertil Steril. 2004 Aug;82(2):405-14. doi: 10.1016/j.fertnstert.2004.02.109.

生育药物的使用与卵巢癌风险：基于丹麦人群的队列研究

Use of fertility drugs and risk of ovarian cancer: Danish Population Based Cohort Study.

作者信息

Jensen Allan, Sharif Heidi, Frederiksen Kirsten, Kjaer Susanne Krüger

机构信息

Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100, Copenhagen, Denmark.

出版信息

BMJ. 2009 Feb 5;338:b249. doi: 10.1136/bmj.b249.

DOI:10.1136/bmj.b249
PMID:19196744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2640154/
Abstract

OBJECTIVE

To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women.

DESIGN

Population based cohort study.

SETTING

Danish hospitals and private fertility clinics.

PARTICIPANTS

54,362 women with infertility problems referred to all Danish fertility clinics during 1963-98. The median age at first evaluation of infertility was 30 years (range 16-55 years), and the median age at the end of follow-up was 47 (range 18-81) years. Included in the analysis were 156 women with invasive epithelial ovarian cancer (cases) and 1241 subcohort members identified in the cohort during follow-up in 2006.

MAIN OUTCOME MEASURE

Effect of four groups of fertility drugs (gonadotrophins, clomifene citrate, human chorionic gonadotrophin, and gonadotrophin releasing hormone) on overall risk of ovarian cancer after adjustment for potential confounding factors.

RESULTS

Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing hormone (0.80, 0.42 to 1.51). Furthermore, no associations were found between all four groups of fertility drugs and number of cycles of use, length of follow-up, or parity.

CONCLUSION

No convincing association was found between use of fertility drugs and risk of ovarian cancer.

摘要

目的

利用一大群不孕女性的数据，研究生育药物对卵巢癌总体风险的影响。

设计

基于人群的队列研究。

地点

丹麦医院及私立生育诊所。

参与者

1963年至1998年间转诊至丹麦所有生育诊所的54362名有不孕问题的女性。首次评估不孕时的中位年龄为30岁（范围16 - 55岁），随访结束时的中位年龄为47岁（范围18 - 81岁）。分析纳入了156名侵袭性上皮性卵巢癌女性（病例）以及2006年随访期间在队列中确定的1241名亚队列成员。

主要观察指标

在调整潜在混杂因素后，四组生育药物（促性腺激素、枸橼酸氯米芬、人绒毛膜促性腺激素和促性腺激素释放激素）对卵巢癌总体风险的影响。

结果

队列内分析显示，使用任何促性腺激素（率比0.83，95%置信区间0.50至1.37）、氯米芬（1.14，0.79至1.64）、人绒毛膜促性腺激素（0.89，0.62至1.29）或促性腺激素释放激素（0.80，0.42至1.51）后，卵巢癌总体风险均未增加。此外，在所有四组生育药物与使用周期数、随访时间长度或产次之间未发现关联。

结论

未发现生育药物使用与卵巢癌风险之间存在令人信服的关联。