Corba J
Vet Med (Praha). 1976 Sep;21(9):537-44.
The reports deals with the results of testing seven new antihelminthics for Fasciola hepatica in the experimentally invaded Wistar rat. The greatest influence on juvenile flukes (2 and 4 weeks of age) was exerted by diamphenetid (Coriban) applied in a single dose of 100 mg kg-1. Hexachlorophene applied in the dose of 50 mg kg-1 showed the highest effect on sexually mature flukes. All the tested antihelminthics of the halogenated salicylanilide group were ineffective on juvenile stages and only slightly effective on mature F. hepatica flukes. It follows from the results that the effectiveness of some antifasciolics on laboratory animals need not always be in correlation with their effect in ruminants - hence it is necessary to verify the results obtained in laboratory animals and to check them on natural F. hepatica hosts.
该报告涉及在实验性感染肝片吸虫的Wistar大鼠中测试七种新型抗肝片吸虫药物的结果。单剂量100 mg kg-1的碘胺酚（Coriban）对幼年吸虫（2周龄和4周龄）影响最大。50 mg kg-1剂量的六氯酚对性成熟吸虫效果最佳。所有测试的卤化水杨酰苯胺类抗蠕虫药对幼年阶段无效，对成熟肝片吸虫仅略有效果。结果表明，某些抗肝片吸虫药对实验动物的有效性不一定总是与其在反刍动物中的效果相关——因此有必要核实实验动物中获得的结果，并在肝片吸虫的天然宿主上进行检验。
