Zhang Junping, Narayan Roger J
Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC 27599, USA.
J Nanosci Nanotechnol. 2008 Nov;8(11):6048-51. doi: 10.1166/jnn.2008.482.
In this work, a DNA lattice was utilized to direct protein self-assembly. A model biosensor system was fabricated by self-assembly of rhodamine dye-labeled streptavidin molecules on a two-tile DNA system. This self-assembly nanofabrication technique has numerous possible biotechnology applications, including use in multiplex biosensing systems that have binding of several biological molecules encoded in a multiple-tile DNA lattice.
在这项工作中，利用DNA晶格来指导蛋白质自组装。通过在双瓦片DNA系统上自组装罗丹明染料标记的链霉亲和素分子，构建了一个模型生物传感器系统。这种自组装纳米制造技术有许多可能的生物技术应用，包括用于多重生物传感系统，该系统可结合多瓦片DNA晶格中编码的几种生物分子。
