Doster Meghan E, Johnson Samuel A
Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, N9B 3P4, Canada.
Angew Chem Int Ed Engl. 2009;48(12):2185-7. doi: 10.1002/anie.200806048.
N, not NHC: A neutral, basic, strong sigma-donor nitrogen ancillary ligand with properties analogous to those of N-heterocyclic carbenes (NHCs) was developed to aid in the oxidative additions of challenging substrates to late transition metals. Selective, room-temperature C-F bond activation was observed with hexa-, penta-, and all three isomers of tetrafluorobenzene using a nickel(0) source in the presence of this donor.
N，而非NHC：一种中性、碱性、强σ供体氮辅助配体被开发出来，其性质与N-杂环卡宾（NHCs）类似，用于协助具有挑战性的底物向晚期过渡金属的氧化加成反应。在该供体存在的情况下，使用镍（0）源时，观察到六氟苯、五氟苯以及四氟苯的所有三种异构体在室温下发生了选择性C-F键活化。
