Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
J Am Chem Soc. 2009 Mar 4;131(8):2786-7. doi: 10.1021/ja809176m.
The catalytic enantioselective intramolecular ring-opening of oxetanes with alcohols is catalyzed by (salen)Co(III) complexes. Either a monomeric or oligomeric catalyst can be used successfully in this transformation, providing 3-substituted tetrahydrofurans in both high yield and enantioselectivity. This methodology extends the range of electrophiles that can be activated toward highly enantioselective addition reactions by (salen)metal catalysts to an important new class.
(手性水杨醛亚胺)钴(III)配合物可以催化环氧化合物与醇的催化对映选择性分子内环开反应。在该转化中,无论是单体催化剂还是齐聚物催化剂都能成功使用,以高产率和对映选择性提供 3-取代的四氢呋喃。该方法将(手性水杨醛亚胺)金属催化剂可以活化的亲电试剂的范围扩展到一类重要的新化合物,以实现高度对映选择性加成反应。