Chemical Engineering and Process Development Division, National Chemical Laboratory, Dr Homi Bhabha Road, Pune 411008, India.
Org Biomol Chem. 2014 Apr 21;12(15):2349-55. doi: 10.1039/c3ob42501k.
The salen Co(III)-catalyzed phenolic kinetic resolution of racemic anti- or syn-azido and benzyloxy epoxides provides a practical route to a range of enantioenriched anti- or syn-1-aryloxy-3-azido or benzyloxy-2-alcohols in excellent yields and ees. The synthetic potential of this protocol is illustrated with an enantioselective synthesis of ICI-118,551, a β-blocker, in a highly optically pure form (99% ee).
手性水杨醛钴（III）催化的外消旋反式或顺式叠氮基和苄氧基环氧的动力学拆分，为一系列对映体富集的反式或顺式 1-芳氧基-3-叠氮基或苄氧基-2-醇提供了一种实用的方法，产率和对映选择性都很高。该方案的合成潜力通过以高度光学纯形式（99%ee）对β阻断剂 ICI-118,551 的对映选择性合成得到了说明。
