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活动性肺结核期间γ干扰素的产生受涉及白细胞介素-17、信号淋巴细胞激活分子和环磷腺苷效应元件结合蛋白的机制调控。

IFN-gamma production during active tuberculosis is regulated by mechanisms that involve IL-17, SLAM, and CREB.

作者信息

Pasquinelli Virginia, Townsend James C, Jurado Javier O, Alvarez Ivana B, Quiroga María F, Barnes Peter F, Samten Buka, García Verónica E

机构信息

Department of Biological Chemistry, School of Sciences, University of Buenos Aires, Buenos Aires, Argentina.

出版信息

J Infect Dis. 2009 Mar 1;199(5):661-5. doi: 10.1086/596742.

DOI:10.1086/596742
PMID:19199539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5488291/
Abstract

Interferon-gamma (IFN-gamma) is crucial for protection against Mycobacterium tuberculosis, and the transcription factor cAMP response element binding protein (CREB) increases IFN-gamma transcription. We determined whether the transmembrane receptor signaling lymphocyte activation molecule (SLAM) and interleukin-17 (IL-17) affect CREB phosphorylation and IFN-gamma production in persons with tuberculosis. When T cells from patients with tuberculosis were activated with M. tuberculosis, 80% of SLAM(+) T cells expressed phosphorylated CREB, and SLAM activation increased CREB phosphorylation and IFN-gamma production. In contrast, IL-17 down-regulated SLAM expression, CREB phosphorylation, and IFN-gamma production. Therefore, IL-17 and SLAM have opposing effects on IFN-gamma production through CREB activation in persons with tuberculosis.

摘要

干扰素-γ（IFN-γ）对于抵抗结核分枝杆菌至关重要，转录因子环磷酸腺苷反应元件结合蛋白（CREB）可增加IFN-γ的转录。我们确定了跨膜受体信号淋巴细胞激活分子（SLAM）和白细胞介素-17（IL-17）是否影响结核病患者的CREB磷酸化和IFN-γ产生。当用结核分枝杆菌激活结核病患者的T细胞时，80%的SLAM(+) T细胞表达磷酸化的CREB，并且SLAM激活增加了CREB磷酸化和IFN-γ产生。相比之下，IL-17下调了SLAM表达、CREB磷酸化和IFN-γ产生。因此，在结核病患者中，IL-17和SLAM通过激活CREB对IFN-γ产生具有相反的作用。

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J Immunol. 2008 Aug 1;181(3):2056-64. doi: 10.4049/jimmunol.181.3.2056.
2
Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.不同的、产生特定白细胞介素-17和白细胞介素-22的CD4+ T细胞亚群有助于人类抗分枝杆菌免疫反应。
J Immunol. 2008 Feb 1;180(3):1962-70. doi: 10.4049/jimmunol.180.3.1962.
3
IL-23 and IL-17 in the establishment of protective pulmonary CD4+ T cell responses after vaccination and during Mycobacterium tuberculosis challenge.白细胞介素-23和白细胞介素-17在疫苗接种后及结核分枝杆菌攻击期间保护性肺CD4+T细胞反应的建立过程中的作用
Nat Immunol. 2007 Apr;8(4):369-77. doi: 10.1038/ni1449. Epub 2007 Mar 11.
4
IL-17-mediated regulation of innate and acquired immune response against pulmonary Mycobacterium bovis bacille Calmette-Guerin infection.白细胞介素-17介导的针对肺部卡介苗感染的先天性和获得性免疫反应的调节
J Immunol. 2007 Mar 15;178(6):3786-96. doi: 10.4049/jimmunol.178.6.3786.
5
A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage.辅助性T细胞17简史，这是T细胞介导的组织损伤的辅助性T细胞1/辅助性T细胞2假说的首次重大修订。
Nat Med. 2007 Feb;13(2):139-45. doi: 10.1038/nm1551.
6
Cyclic AMP response element-binding protein positively regulates production of IFN-gamma by T cells in response to a microbial pathogen.环磷腺苷效应元件结合蛋白可正向调节T细胞针对微生物病原体产生γ干扰素的过程。
J Immunol. 2005 May 15;174(10):6357-63. doi: 10.4049/jimmunol.174.10.6357.
7
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8
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9
Analysis of gene function in somatic mammalian cells using small interfering RNAs.利用小干扰RNA分析哺乳动物体细胞中的基因功能。
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10
Transcription: tantalizing times for T cells.转录：T细胞的诱人时刻。
Cell. 2002 Apr;109 Suppl:S109-20. doi: 10.1016/s0092-8674(02)00705-5.