酶和钌催化的 1,5-二醇的动态动力学不对称转化。在（+）-Solenopsin A 合成中的应用。
Enzyme- and ruthenium-catalyzed dynamic kinetic asymmetric transformation of 1,5-diols. Application to the synthesis of (+)-Solenopsin A.
机构信息
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
出版信息
J Org Chem. 2009 Mar 6;74(5):1988-93. doi: 10.1021/jo8025109.
PMID:19199656
Abstract
Dynamic kinetic asymmetric transformation (DYKAT) of 1,5-diols via combined lipase and ruthenium catalysis provides enantiomerically pure diacetates in high diastereoselectivity, which can serve as intermediates in natural product synthesis. This is demonstrated by the synthesis of (+)-Solenopsin A.
摘要
通过脂肪酶和钌催化的联合反应，对 1,5-二醇进行动态动力学不对称转化（DYKAT），可以高非对映选择性地得到对映体纯的二乙酸酯，这些二乙酸酯可以作为天然产物合成的中间体。这一点通过（+）-Solenopsin A 的合成立即得到了证明。
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