手性磷酸催化的酰胺的高对映选择性氢化反应。
Highly enantioselective hydrogenation of enamides catalyzed by chiral phosphoric acids.
机构信息
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, USA.
出版信息
Org Lett. 2009 Mar 5;11(5):1075-8. doi: 10.1021/ol802860u.
Abstract
A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral-achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.
摘要
发展了一种由双手性-非手性酸体系催化的高对映选择性烯酰胺氢化反应。通过使用亚化学计量的手性磷酸和乙酸，只需 1 mol%的手性催化剂即可实现催化剂的低负载量，从而为还原产物提供优异的产率和对映选择性。
Zotero 插件