类固醇组学在神经退行性疾病和衰老研究中的重要性。
The importance of steroidomics in the study of neurodegenerative disease and ageing.
作者信息
Griffiths William J, Wang Yuqin
机构信息
Institute of Mass Spectrometry, School of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA28PP, UK.
出版信息
Comb Chem High Throughput Screen. 2009 Feb;12(2):212-28. doi: 10.2174/138620709787315472.
In this mini review, the importance of experimental steroidomics in the study of neurodegenerative disease and aging is discussed. Attention is focused on just one class of lipid which is based on the cyclopentanoperhydro-phenanthrene ring system. Experimental methods for steroidomic analysis are reviewed, and the potential to use these methods to diagnose disease and to gain a better understanding of neurodegenerative disorders is examined.
在本综述中，讨论了实验性类固醇组学在神经退行性疾病和衰老研究中的重要性。重点关注基于环戊烷多氢菲环系统的一类脂质。综述了类固醇组学分析的实验方法，并探讨了使用这些方法诊断疾病以及更好地理解神经退行性疾病的潜力。
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