Martin Mauricio, Dotti Carlos G, Ledesma Maria Dolores
Department of Molecular and Developmental Genetics, VIB, 3000 Leuven, Belgium.
Biochim Biophys Acta. 2010 Aug;1801(8):934-44. doi: 10.1016/j.bbalip.2010.03.011. Epub 2010 Mar 30.
Correct lipid homeostasis at the plasma membrane is essential for cell survival and performance. These are critically challenged in the aging brain. Changes in the levels of cholesterol, a major membrane component especially enriched in neurons, accompany the brain aging process. They also occur in neurodegenerative diseases. Understanding the causes and consequences of these changes is a crucial step when trying to delay the cognitive decline, which comes with age, or to design strategies to fight neurodegenerative disorders such as Alzheimer's disease. We here review work that has contributed to this understanding.
维持质膜上正确的脂质稳态对于细胞存活和功能发挥至关重要。在衰老的大脑中，这些方面受到了严峻挑战。胆固醇是一种主要的膜成分，在神经元中尤其丰富，其水平的变化伴随着大脑衰老过程。在神经退行性疾病中也会出现这种变化。在试图延缓与年龄相关的认知衰退或设计对抗诸如阿尔茨海默病等神经退行性疾病的策略时，了解这些变化的原因和后果是关键的一步。我们在此回顾有助于这一理解的相关研究工作。
