抗糖皮质激素、神经发生与抑郁症
Antiglucocorticoids, neurogenesis and depression.
作者信息
Fitzsimons Carlos P, van Hooijdonk Lenneke W A, Morrow John A, Peeters Bernard W M M, Hamilton Niall, Craighead Mark, Vreugdenhil Erno
机构信息
LACDR/Medical Pharmacology Department, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333CC Leiden, The Netherlands.
出版信息
Mini Rev Med Chem. 2009 Feb;9(2):249-64. doi: 10.2174/138955709787316001.
Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.
最近的证据表明，抗糖皮质激素与传统抗抑郁药一样，可能通过促进海马神经发生来缓解抑郁症状。在此，我们探讨几种基于抗糖皮质激素的抗抑郁治疗策略。首先，我们回顾特定的糖皮质激素受体/拮抗剂相互作用。其次，我们讨论一个潜在的新治疗靶点——双皮质素样激酶，它在神经元祖细胞中调节糖皮质激素信号传导。
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